How is DNA translated
Psychotropic substances interact with numerous mechanisms within the central nervous system (CNS), such as neurotransmitter synthesis or storage within the synapses, the effects of degrading enzymes, the specific pre- and postsynaptic receptors and transport proteins.
This variety of possible reactions means that variations in the DNA sequence of one or more of these candidate genes can have numerous effects, such as changes in the concentration or function of the neurotransmitters or enzymes, the binding properties of the receptors or transporters.
Newer concepts in pharmacogenetics focus primarily on the proteins beyond the postsynaptic membrane, such as signal transduction and neuronal and synaptic plasticity.www.klinikum.uni-muenchen.de
Psychotropic substances interact with numerous mechanisms within the central nervous system (CNS), such as neurotransmitter synthesis or storage in synapses, with the effects of degrading enzymes and with specific pre- and postsynaptic receptors, as well as transport proteins.
This wide range of possible reactions implies that variations in the DNA sequence of one or several of these candidate genes can have numerous consequences, such as changes in the concentration or function of neurotransmitters or enzymes, in the binding properties of receptors and transporters.
Newer concepts of pharmacogenetics concentrate primarily on mechanisms beyond the postsynaptic membrane, such as signal transduction, as well as neuronal and synaptic plasticity.www.klinikum.uni-muenchen.de
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